Pharmacodynamic interactions of sublingual apomorphine with oral antihypertensive agents and nitrates

Comparing oral captopril and sublingual nitrates in controlling urgent

Introduction: Hypertension crisis is one of the most common reasons of the patient’s reference to emergency units. Many intravenous and oral drugs are available for controlling hypertension crisis. Intravenous nitrates are one of these drugs but there are few studies regarding the effect of oral nitrates on hypertension crisis. This study compares the effect of oral captopril and sublingual i...

Drug interactions of antihypertensive agents

Adverse drug-drug interactions may occur when a major therapeutic mechanism of one drug class (such as bradycardia with a beta blocker) is excessively exaggerated by the addition of another heart-rate slowing antihypertensive, such as verapamil. The most important interactions at the molecular level are those of the hepatic enzyme, cytochrome (CYP) 3A4. A classic example is the inhibitory effec...

Interactions between antihypertensive agents and other drugs.

Comparative evaluation of sublingual long-acting nitrates.

Ten hospitalized patients performed two exercise tests per day on five consecutive days to determine the efficacy and duration of action of three sublingual long-acting nitrate preparations: isosorbide dinitrate, pentaerythritol trinitrate, and erythrityl tetranitrate. The duration of exercise to the point of ischemia, manifest as typical anginal pain and/or 1.0 mm ST-segment depression, was de...

Pharmacokinetic-pharmacodynamic Modeling of Antihypertensive Drugse

Knowledge of pharmacokinetic-pharmacodynamic (PK/PD) properties of antihypertensive drugs may optimize drug therapy of hypertension. PK/PD modeling in clinical research could contribute in drug development and clinical practice in several aspects, including an evaluation of the efficacy and safety of antihypertensive agents, enhancement of information during the development process, identificat...